Banting Medal for Scientific Achievement Award
Bruce M. Spiegelman, PhD
The Banting Medal for Scientific Achievement is the Association’s highest scientific award, recognizing significant, long-term contributions to the understanding, treatment, or prevention of diabetes. Dr. Spiegelman is currently the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at Harvard Medical School and the Dana-Farber Cancer Institute, Boston, Massachusetts.
Dr. Spiegelman has been at the forefront of the revolution in molecular metabolism for over a quarter of a century. His trail-blazing insights into the role of adipose tissue and adipokines in systemic metabolism, and the transcriptional basis of adipose development and physiology, continue to reverberate in the study of obesity, diabetes, and insulin resistance.
Dr. Spiegelman was the first to suggest that inflammation (represented by TNF-α) lies at the heart of insulin resistance. He also identified PPARγ as the master regulator of adipogenesis, described the role of its co-activator PGC-1 in energy homeostasis and thermogenesis, and identified the transcription factor PRDM16 as the determining factor for brown adipose tissue development.
The insights provided by Dr. Spiegelman have led to numerous drug discovery efforts that will improve diabetes prevention and treatment for years to come. His discoveries have also generated powerful tools and concepts that allow many others in related fields to advance their studies.