Samuel Rahbar Outstanding Discovery Award
Samuel Rahbar, MD, PhD
This year, the Association is bestowing a special, one-time National Scientific Achievement Award, the Samuel Rahbar Outstanding Discovery Award presented to its namesake, Samuel Rahbar, MD, PhD, in recognition of his discovery of HbA1c as a marker of glycemic status in patients with diabetes.
In 1968, Dr. Rahbar reported the observation that a rare, fast-moving glycated fraction of hemoglobin, HbA1c, was increased in patients with diabetes. Dr. Rahbar’s discovery provided the basis for future work that determined that HbA1c was a clinically useful marker for long-term glycemic status, and development of the standardized clinical assay that is now used routinely in clinical practice.
From Dr. Rahbar’s work, physicians and patients were given a critical tool to monitor glycemic control over a period of time, and measurement of HbAlc has become the gold standard for assessing the effectiveness of new diabetic therapies since its standardized use in the Diabetes Control and Complications Trial. HbA1c is also recommended for diagnosis of diabetes and is superior to fasting glucose as a risk factor in cardiovascular disease.
Currently distinguished professor of diabetes, Department of Diabetes, Endocrinology, and Metabolism, City of Hope, Duarte, Calif., Dr. Rahbar continues to make valuable contributions. His identification of glycated hemoglobin opened an new area of basic and translational research into advanced glycated endproducts (AGEs), advanced lipoxidation endproducts (ALEs), and DNA-AGEs adducts