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Extended-Release MetforminWhat is the problem and what is known about it so far?High blood glucose levels and uncontrolled diabetes can lead to serious health problems, such as heart disease, eye disease, nerve disease, kidney disease, and depression. Why did the researchers do this particular study?Metformin is the most frequently prescribed drug to help people with diabetes lower their blood glucose levels. Commonly prescribed metformin is absorbed by the body over a period of 4 hours or less. The researchers of this study wanted to see how safe and effective "extended-release" metformin is. Extended-release metformin is absorbed by the body over a period of about 8 hours. Who was studied?More than 700 adults with type 2 diabetes. How was the study done?The patients were given either extended-release metformin (1,500 milligrams once a day, 1,500 milligrams twice a day, or 2,000 milligrams once a day) or were given metformin that's immediately absorbed by the body (1,500 milligrams twice a day). The study lasted for 24 weeks. What did the researchers find?After 12 weeks, all of the patients had decreases in their blood glucose levels. The patients who took a 2,000-milligram dose once a day of extended-release metformin had the largest decreases. What were the limitations of the study?In this study, it was not possible to make sure that all of the patients were sticking to their treatment routine. What are the implications of the study?Extended-release metformin, taken either once or twice a day, is just as safe and effective as regular metformin taken twice day. FOR MORE INFORMATIONOther Medications for Type 2 Diabetes Beating the Odds on Heart Disease: When It Comes to Living Longer, Staying Active Is Key 101 Medication Tips for People With Diabetes |
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