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Uncontrolled Glucose Levels Can Lead to Peripheral Arterial Disease


HbA1c and peripheral arterial disease in diabetes: the Atherosclerosis Risk in Communities study, by E. Selvin and colleagues. Diabetes Care 29:877-882, 2006.


What is the problem and what is known about it so far?


Peripheral arterial disease (also known as PAD) occurs when blood vessels in the legs are narrowed or blocked by fatty deposits. PAD is twice as common in people with diabetes and can lead to heart and blood vessel disease.

Why did the researchers do this particular study?


The researchers wanted to find out if having high blood glucose levels can lead to PAD.

Who was studied?


Nearly 2,000 middle-aged adults with diabetes who took part in the Atherosclerosis Risk in Communities Study.

How was the study done?


The people who took part in the study had their fasting and long-term blood glucose levels measured, and the researchers determined if they had PAD.

What did the researchers find?


The researchers found that having high blood glucose levels raises the chances of getting PAD. High blood glucose levels were more commonly found in people who had strong symptoms of PAD, like claudication (pain or fatigue in the arms or legs because of decreased blood flow), and in people who’ve had to go to the hospital because of PAD.

What were the limitations of the study?


Not all symptoms of PAD were regularly checked on by the researchers. Also, when the study took place, there were different standards for diagnosing diabetes.

What are the implications of the study?


There is a link between high blood glucose levels and getting PAD. Efforts to improve your blood glucose levels (like losing weight through diet and exercise) can also help lower your chances of getting PAD.

FOR MORE INFORMATION


All About Peripheral Arterial Disease

Diabetes, Heart Disease, and Strok

Beating the Odds on Heart Disease: When It Comes to Living Longer, Staying Active Is Key

Keeping Your Heart Healthy Despite Diabetes



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