Perspectives in Diabetes
Volume 1 (1988-1992)
Documents denoted with (PDF) require Adobe Acrobat software.
1988
January
SA Metz
Is protein kinase C required for physiologic insulin release? (PDF)
February
WS Zawalich
Modulation of insulin secretion from beta-cells by phosphoinositide-derived second-messenger molecules (PDF)
March
AA Rossini, JP Mordes, and ES Handler
Speculations on etiology of diabetes mellitus. Tumbler hypothesis (PDF)
April
RP Robertson
Eicosanoids as pluripotential modulators of pancreatic islet function (PDF)
May
DL Cook, LS Satin, ML Ashford, and CN Hales
ATP-sensitive K+ channels in pancreatic beta-cells. Spare-channel hypothesis (PDF)
June
DA Greene, SA Lattimer, and AA Sima
Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy? (PDF)
July
AE Boyd
Sulfonylurea receptors, ion channels, and fruit flies (PDF)
August
M Segall
HLA and genetics of IDDM. Holism vs. reductionism? (PDF)
September
BE Dunning and GJ Taborsky
Galanin-sympathetic neurotransmitter in endocrine pancreas? (PDF)
October
ML McDaniel, JH Hughes, BA Wolf, RA Easom, and JW Turk
Descriptive and mechanistic considerations of interleukin 1 and insulin secretion (PDF)
December
NK Maclaren
How, when, and why to predict IDDM (PDF)
1989
January
O Minkowski
Historical development of the theory of pancreatic diabetes by Oscar Minkowski, 1929: introduction and translation by Rachmiel Levine (PDF)
February
KR Feingold
Importance of small intestine in diabetic hypercholesterolemia (PDF)
March
WG Blackard, CO Barlascini, JN Clore, and JE Nestler
Morning insulin requirements. Critique of dawn and meal phenomena (PDF)
April
PE Cryer
Decreased sympathochromaffin activity in IDDM (PDF)
May
L Axelrod
Omega-3 fatty acids in diabetes mellitus. Gift from the sea? (PDF)
June
GM Grodsky
A new phase of insulin secretion. How will it contribute to our understanding of beta-cell function? (PDF)
July
LC Harrison, IL Campbell, J Allison, and JF Miller
MHC molecules and beta-cell destruction. Immune and nonimmune mechanisms (PDF)
August
NJ Cox and GI Bell
Disease associations. Chance, artifact, or susceptibility genes? (PDF)
September
MW Steffes, R Osterby, B Chavers, and SM Mauer
Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients (PDF)
October
RL Engerman
Pathogenesis of diabetic retinopathy (PDF)
November
D Porte and SE Kahn
Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction? (PDF)
December
RP Robertson
Type II diabetes, glucose "non-sense," and islet desensitization (PDF)
1990
January
M Mueckler
Family of glucose-transporter genes. Implications for glucose homeostasis and diabetes (PDF)
January
Y Shechter
Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes (PDF)
February
S Seino, M Seino, and GI Bell
Human insulin-receptor gene (PDF)
March
MK Hostetter
Handicaps to host defense. Effects of hyperglycemia on C3 and Candida albicans (PDF)
April
GC Weir, S Bonner-Weir, and JL Leahy
Islet mass and function in diabetes and transplantation (PDF)
May
MA Magnuson
Glucokinase gene structure. Functional implications of molecular genetic studies (PDF)
June
FM Matschinsky
Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes (PDF)
July
CE Mogensen
Prediction of clinical diabetic nephropathy in IDDM patients. Alternatives to microalbuminuria? (PDF)
August
MA Lipes and GS Eisenbarth
Transgenic mouse models of type I diabetes (PDF)
September
JM Olefsky
The insulin receptor. A multifunctional protein (PDF)
October
GT Nepom
A unified hypothesis for the complex genetics of HLA associations with IDDM (PDF)
November
SS Rich
Mapping genes in diabetes. Genetic epidemiological perspective (PDF)
December
MJ MacDonald
Elusive proximal signals of beta-cells for insulin secretion (PDF)
1991
January
RP Robertson, ER Seaquist, and TF Walseth
G proteins and modulation of insulin secretion (PDF)
February
M Wendorf and ID Goldfine
Archaeology of NIDDM. Excavation of the "thrifty" genotype (PDF)
March
KH Johnson, TD O'Brien, and P Westermark
Newly identified pancreatic protein islet amyloid polypeptide. What is its relationship to diabetes? (PDF)
March
DF Steiner, S Ohagi, S Nagamatsu, GI Bell, and M Nishi
Is islet amyloid polypeptide a significant factor in pathogenesis or pathophysiology of diabetes? (PDF)
April
JW Baynes
Role of oxidative stress in development of complications in diabetes (PDF)
May
JH Exton
Some thoughts on the mechanism of action of insulin (PDF)
June
M Lorenzi and E Cagliero
Pathobiology of endothelial and other vascular cells in diabetes mellitus. Call for data (PDF)
July
GG Pinter and JL Atkins
Role of postglomerular microvessels in pathophysiology of diabetic nephropathy. Assessment and hypothesis (PDF)
August
JP Palmer and DK McCulloch
Prediction and prevention of IDDM -- 1991 (PDF)
September
RP Robertson
Pancreas transplantation in humans with diabetes mellitus (PDF)
October
L Axelrod
Insulin, prostaglandins, and the pathogenesis of hypertension (PDF)
November
RL Sorenson, DG Garry, and TC Brelje
Structural and functional considerations of GABA in islets of Langerhans. Beta-cells and nerves (very large PDF)
December
SA Metz
The pancreatic islet as Rubik's Cube. Is phospholipid hydrolysis a piece of the puzzle? (PDF)
1992
January
RP Robertson
History of Diabetes, the Journal (1952-1991) Editor's swan song (PDF)
February
MJ Sheehy
HLA and insulin-dependent diabetes. A protective perspective (PDF)
March
PE Cryer
Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM. A vicious cycle (PDF)
April
NJ Cox, KS Xiang, SS Fajans, and GI Bell
Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young (PDF)
May
AL McCall
The impact of diabetes on the CNS (PDF)
June
WC Duckworth, CD Saudek, and RR Henry
Why intraperitoneal delivery of insulin with implantable pumps in NIDDM? (PDF)
July
DG Pipeleers
Heterogeneity in pancreatic beta-cell population (PDF)
August
JA Corbett and ML McDaniel
Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM (PDF)
September
JA Todd and SC Bain
A practical approach to identification of susceptibility genes for IDDM (PDF)
October
S Misler, DW Barnett, KD Gillis, and DM Pressel
Electrophysiology of stimulus-secretion coupling in human beta-cells (PDF)
November
MA Permutt, KC Chiu, and Y Tanizawa
Glucokinase and NIDDM. A candidate gene that paid off (PDF)
December
RP Lanza, SJ Sullivan, and WL Chick
Perspectives in diabetes. Islet transplantation with immunoisolation (PDF)
