Ruderman, Neil B.
AMPK regulation and biological relevance
General Research Subject: Insulin Resistance Pre Diabetes
Type of Grant: Mentor Based Minority Postdoctoral Fellowship
Project Start Date: July 1, 2011
Project End Date: June 30, 2015
Over the past 15 years, Dr. Ruderman and his colleagues have carried out basic investigations of how fat metabolism is regulated in skeletal muscle, adipose tissue, liver and vascular cells. Their research has been instrumental in implicating abnormalities in fatty acid metabolism in such disorders as insulin resistance, obesity and the early damage to endothelial cells (cells that line the internal surface of arteries) that is thought to initiate premature coronary heart disease in diabetic patients. They have also shown that these abnormalities in fatty acid metabolism very likely involve two molecules: the fuel-sensing enzyme AMP-activated protein kinase (AMPK) and silent information regulator 1 (SIRT1), an enzyme implicated in the protection against aging induced by caloric restriction. Ongoing work is defining how AMPK and SIRT1 regulate each other and how abnormalities in such regulation lead to disease. Efforts are also being made to identify how exercise acutely alters AMPK and SIRT1 in multiple tissues with the intent of understanding how it helps to prevent type 2 diabetes and its vascular complications. Fellows working on these projects utilize a variety of experimental models including cultured endothelial cells, incubated muscles, intact rodents including transgenic mice, and most recently, humans.
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