Maahs, David M., PhD
Use of the Medtronic Database to Estimate the Effect of Overnight Closed Loop Control on Estimated 24-hour Mean Glucose, Estimated A1c, and Glycemic Variability
General Research Subject: Type 1 Diabetes
Focus: Clinical Therapeutics/New Technology, Clinical Therapeutics/New Technology\Glucose Monitoring and Sensing, Clinical Therapeutics/New Technology\Insulin Delivery Systems, Pediatrics\Type 1
Type of Grant: ADA-Medtronic Technology in Diabetes Fellowship
Project Start Date: July 1, 2013
Project End Date: June 30, 2014
Diabetes Type: Type 1 diabetes
A next step in the pathway to achieve an artificial pancreas for home use by patients will be overnight closed loop control. Overnight closed loop control has been shown feasible in hospital settings and more recently in transitional (diabetes camp) settings. Translating Medtronic closed loop technology to an out-patient setting will require numerous studies to demonstrate safety and improved outcomes (reduced hypoglycemia and A1c). While these studies are in process, it is possible to use existing Medtronic data sets (Carelink, Star 3) to simulate the effect of overnight closed loop control on outcomes such as estimated mean 24-hour glucose, estimated A1c, and glycemic variability. Such data will provide further support to accelerate the translation of closed loop technology to future home use by patients with type 1 diabetes.
What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes?
This project will improve our understanding of the association of mean blood glucose to A1c and second how improvement in mean blood glucose by using overnight closed loop control will affect A1c. This will help inform artificial pancreas work.
If a person with diabetes were to ask you how your project will help them in the future,
how would you respond?
This research should add to our understanding of how an artificial pancreas will improve glucose control.
Why is it important for you, personally, to become involved in diabetes research? What role will this award play in your research efforts?
I provide clinical care for children and adolescents with diabetes. Advancing work on an artificial pancreas is important for my patients.
In what direction do you see the future of diabetes research going?
I see improved iterations of the artificial pancreas being available to patients in the not too distant future.
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