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Pathway Publications

Primary Publications

  1. Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metab. 2017 Jul 5;26(1):185-197.e3. doi: 10.1016/j.cmet.2017.05.015. PMID: 28683286
  2. Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A. The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metab. 2017 Jul 5;26(1):198-211.e5. doi: 10.1016/j.cmet.2017.06.015. PMID: 28683287 
  3. Rabbani PS, Zhou A, Borab ZM, Frezzo JA, Srivastava N, More HT, Rifkin WJ, David JA, Berens SJ, Chen R, Hameedi S, Junejo MH, Kim C, Sartor RA, Liu CF, Saadeh PB, Montclare JK, Ceradini DJ. Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing. Biomaterials. 2017 Jul;132:1-15. doi: 10.1016/j.biomaterials.2017.04.001. PMID: 28391065
  4. Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. PMID: 28346406
  5. Wang C, Ye Y, Sun W, Yu J, Wang J, Lawrence DS, Buse JB, Gu Z. Red Blood Cells for Glucose-Responsive Insulin Delivery. Adv Mater. 2017 Mar 7 [epub ahead of print]. DOI: 10.1002/adma.201606617
  6. Varshney A, Scott LJ, Welch RP, Erdos MR, Chines PS, Narisu N, Albanus RD, Orchard P, Wolford BN, Kursawe R, Vadlamudi S, Cannon ME, Didion JP, Hensley J, Kirilusha A; NISC Comparative Sequencing Program., Bonnycastle LL, Taylor DL, Watanabe R, Mohlke KL, Boehnke M, Collins FS, Parker SC, Stitzel ML. Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2301-2306. doi: 10.1073/pnas.1621192114. Epub 2017 Feb 13. PMID: 28193859
  7. Machado LE, Shen TL, Page R, Peti W. The KIM-family Protein Tyrosine Phosphatases use distinct reversible oxidation intermediates: intramolecular or intermolecular disulfide bond formation. J Biol Chem. 2017 Apr 7. pii: jbc.M116.774174. doi: 10.1074/jbc.M116.774174. PMID: 28389559
  8. Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. PMID: 28073831
  9. Wiles TA, Delong T, Baker RL, Bradley B, Barbour G, Powell RL, Reisdorph N, Haskins K. An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. J Autoimmun. 2017 Mar; 78:11-18. PMID: 27802879
  10. Dorfman MD, Krull JE, Douglass JD, Fasnacht R, Lara-Lince F, Meek TH, Shi X, Damian V, Nguyen HT, Matsen ME, Morton GJ, Thaler JP. Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice. Nat Commun. 2017 Feb 22;8:14556. doi: 10.1038/ncomms14556. PMID: 28223698
  11. Choy MS, Li Y, Machado LE, Kunze MB, Connors CR, Wei X, Lindorff-Larsen K, Page R, Peti W. Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol Cell. 2017 Feb 16;65(4):644-658.e5. doi: 10.1016/j.molcel.2017.01.014. PMID: 28212750
  12. Miller WP, Ravi S, Martin TD, Kimball SR, Dennis MD. Activation of the stress response kinase JNK attenuates insulin action in retina through a p70S6K1 dependent mechanism. J Biol Chem. 2017 Feb 3;292(5):1591-1602. doi: 10.1074/jbc.M116.760868. PMID:  27965359
  13. Douglass JD, Dorfman MD, Fasnacht R, Shaffer LD, Thaler JP. Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation. Mol Metab. 2017 Jan 28;6(4):366-373. doi: 10.1016/j.molmet.2017.01.010. eCollection 2017 Apr. PMID: 28377875
  14. Blac, AJ, Gordon BS, Dennis MD, Jefferson LS, and Kimball SR. Regulation of the Protein and mRNA Expression of the mTORC1 Repressor REDD1 in Response to Leucine and Serum. Biochem Biophys Rep. 2016 Dec;8:296-301. doi: 10.1016/j.bbrep.2016.10.003. PMID: 28367506
  15. Cardenas A, Allard C, Doyon M, Houseman EA, Bakulski KM, Perron P, Bouchard L, Hivert MF. Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics. 2016 Nov;11(11):773-779. PMID:  27668573
  16. Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2016 Oct 31. PMID: 27798614
  17. Cardenas A, Allard C, Doyon M, Houseman E, Bakulski KM; Perron P, Bouchard L, Hivert MF. Validation of a DNA Methylation Reference Panel for the Estimation of Nucleated Cells Types in Cord Blood. Epigenetics 2016 Nov; 11(11):773-779. PMID: 27668573
  18. Gwiazda KS, Grier AE, Sahni J, Burleigh SM, Martin U, Yang JG, Popp NA, Krutein MC, Khan IF, Jacoby K, Jensen MC, Rawlings DJ, Scharenberg AM. High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins. Mol Ther. 2016 Sep 29;24(9):1570-80. doi: 10.1038/mt.2016.105. PMID: 27203437
  19. Tan CL, Cooke EK, Leib DE, Lin Y-C, Daly GE, Zimmerman CA, and Knight ZA. Warm-sensitive neurons that control body temperature. Cell. 2016, September 22; 167(1):47-59 PMID: 27616062
  20. Kim HE, Grant AR, Simic MS, Kohnz R, Nomura DK, Durieux J, Riera CE, Sanchez M, Kapernick E, Wolff S and Dillin A. Lipid biosynthesis coordinates a Mitochondrial to Cytosolic Stress Response. Cell. 2016 Sep 8;166(6):1539-1552.e16. PMID: 27610574
  21. Kimball SR, Gordon BS, Moyer JE, Dennis MD, Jefferson LS. Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cell Signal. 2016 Aug;28(8):896-906. PMID: 27010498
  22. Chen Y, Lin Y-C, Zimmerman CA, Essner RA, and Knight ZA. Hunger neurons drive feeding through a sustained, positive reinforcement signal. eLife. 2016, August 24;5. pii: e18640. doi: 10.7554/eLife.18640. PMID: 27554486
  23. Leib DE, and Knight ZA. Rapid sensing of dietary amino acid deficiency does not require GCN2. Cell Reports. 2016, August 23; 16(8): 2051-2. PMID: 27558825
  24. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Fernandez Tajes J, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SC, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MC, Palmer ND, Balkau B, Stancáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VK, Park KS, Saleheen D, So WY, Tam CH, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, van der Schouw YT, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA Jr, Thameem F, Wilson G Sr, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney AS, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, Hrabé de Angelis M, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CN, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RC, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJ, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuler D, McCarthy MI. The genetic architecture of type 2 diabetes. Nature. 2016 Aug 4;536(7614):41-7. PMID: 27398621
  25. Zimmerman CA, Lin YC, Leib DE, Guo L, Huey EL, Daly GE, Chen Y, Knight ZA. Thirst neurons anticipate the homeostatic consequences of eating and drinking. Nature. 2016, August 3; 3;537(7622): 680-684 PMID: 27487211
  26. Peck BC, Sincavage J, Feinstein S, Mah AT, Simmons JG, Lund PK, Sethupathy P. miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway. J Biol Chem. 2016 Jul 29;291(31):15975-84. PMID: 27261459
  27. Tang JC, Drokhlyansky E, Etemad B, Rudolph S, Guo B, Wang S, Ellis EG, Li JZ, Cepko CL. Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. eLife. 2016; May 20;5. PMID: 27205882
  28. White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, Ilkayeva O, George T, Muehlbauer MJ, Bain JR, Trimmer JK, Brosnan MJ, Rolph TP, Newgard CB.  Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Mol Metab. 2016 Apr 22;5(7):538-51. PMID: 27408778
  29. Powe CE, Allard C, Battista MC, Doyon M, Bouchard L, Ecker JL, Perron P, Florez JC, Thadhani R, Hivert MF. Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus. Diabetes Care. 2016 Jun;39(6):1052-5. PMID: 27208340
  30. Scott LJ, Erdos MR, Huyghe JR, Welch RP, Beck AT, Wolford BN, Chines PS, Didion JP, Narisu N, Stringham HM, Taylor DL, Jackson AU, Vadlamudi S, Bonnycastle LL, Kinnunen L, Saramies J, Sundvall J, Albanus RD, Kiseleva A, Hensley J, Crawford GE, Jiang H, Wen X, Watanabe RM, Lakka TA, Mohlke KL, Laakso M, Tuomilehto J, Koistinen HA, Boehnke M, Collins FS, Parker SC. The genetic regulatory signature of type 2 diabetes in human skeletal muscle. Nat Commun. 2016 Jun 29;7:11764. PMID: 27353450
  31. Szodoray P, Stanford SM, Molberg Ø, Munthe LA, Bottini N, Nakken B. T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. J Allergy Clin Immunol. 2016 Apr 4. pii: S0091-6749(16)00307-9. PMID: 27056269
  32. Ye Y, Yu J, Wang C, Nguyen NY, Walker GM, Buse JB, Gu Z. Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery. Adv Mater. 2016 Apr;28(16):3115-21. PMID: 26928976
  33. Soares MA, Cohen OD, Low YC, Sartor RA, Ellison T, Anil U, Anzai L, Chang JB, Saadeh PB, Rabbani PS, Ceradini DJ. Restoration of Nrf2 signaling normalizes the regenerative niche. Diabetes. 2016 Mar;65(3):633-46. PMID: 26647385
  34. Miller, WP, Mihailescu, ML, Yang, C, Barber, AJ, Kimball, SR, Jefferson, LS and Dennis, MD.  The Translational Repressor 4E-BP1 contributes to diabetes-induced visual dysfunction. Invest Ophthalmol Vis Sci 2016 Mar;57(3):1327-37. PMID: 26998719
  35. Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science. 2016 Feb 12;351(6274): 676-8. PMID: 26912858
  36. Moore JA, Miller WP, Dennis MD. Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells. Cell Signal. 2016 May;28(5):384-90. PMID: 26852666
  37. Gao M, Nguyen TT, Suckow MA, Wolter WR, Gooyit M, Mobashery S, Chang M. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15226-31. PMID: 26598687
  38. Di J, Yu J, Ye Y, Ranson D, Jindal A, Gu Z. Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles. Cellular and Molecular Bioengineering. 2015 (Cover Feature; Young Innovators Special Issue).
  39. Di J, Yao S, Ye Y, Cui Z, Yu J, Ghosh TK, Zhu Y, Gu Z. Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots. ACS Nano. 2015.  PMID: 26258579
  40. Yu J, Zhang Y, Ye Y, DiSanto R, Sun W, Ranson D, Ligler F, Buse J, Gu Z. Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles Provide Fast Glucose-Responsive Insulin Delivery, Proc Natl Acad Sci U S A, 2015 112(8260) PMID: 26100900
  41. Krishnan N, Miller DH, Kragelj K, Ringkjøbing Jensen M, Gauss K, Xue B, Muthuswamy, SK, Page R, Blackledge M, Peti W, Tonks NK. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 2014 10(7), 558-566. (IF=12.996) PMID: 24845231
  42. Krishnan N, Krishnan K, Connors CR, Choy MS, Page R, Peti W, van Aelst L, Shea SD, & Tonks NT. Targeting BDNF signaling through inhibition of PTP1B suggests a novel therapeutic strategy for treatment of Rett syndrome, Journal of Clinical Investigation, 2015 125(8), 3163-3177. PMID: 26214522
  43. Quang DX, Erdos MR, Parker SC, Collins FS. Motif signatures in stretch enhancers are enriched for disease-associated genetic variants. Epigenetics Chromatin. 2015 Jul 16;8:23. PMID: 2618055
  44. Dennis MD, Kimball SR, Fort PE, Jefferson LS. Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. J Biol Chem. 2015Feb 6;290(6):3865-74. PMID: 25548280
  45. Dennis MD, Coleman CS, Jefferson LS, Kimball SR. REDD1 Enhances Protein Phosphatase 2A (PP2A)-Mediated Dephosphorylation of Akt to Repress mTORC1 Signaling. Science Signaling, 2014 Jul 22;7(335):ra68. PMID: 25056877




Reviews and Perspectives

  1. Meisel JE, Chang M. Selective Small-Molecule Inhibitors as Chemical Tools to Define the Roles of Matrix Metalloproteinases in Disease. Biochim Biophys Acta. 2017 Apr 20. pii: S0167-4889(17)30105-2. doi: 10.1016/j.bbamcr.2017.04.011. Review. PMID: 28435009
  2. Nguyen TT, Mobashery S, Chang M. Roles of Matrix Metalloproteinases in Cutaneous Wound Healing. In "Wound Healing: New Insights into Ancient Challenges", Alexandrescu, V. A. (Editor), 2016, Chapter 3, p. 37-71, http://dx.doi.org/10.5772/64611. InTech Publisher, ISBN 978-953-51-2679-9.
  3. Sethupathy P. The Promise and Challenge of Therapeutic MicroRNA Silencing in Diabetes and Metabolic Diseases. Curr Diab Rep. 2016 Jun;16(6):52. doi: 10.1007/s11892-016-0745-3. Review. PMID: 27112956s
  4. Chang M. Restructuring of the extracellular matrix in diabetic wounds and healing: A perspective. Pharmacol Res. 2016 May;107:243-8. doi: 10.1016/j.phrs.2016.03.008. Epub 2016 Mar 24. PMID: 27033051
  5. Riera CE, Dillin A. Emerging Role of Sensory Perception in Aging and Metabolism. Trends Endocrinol Metab. 2016 May;27(5):294-303. Review. PMID: 27067041
  6. Riera CE, Dillin A. (2015) Tipping the metabolic scales towards increased longevity in mammals. Nature Cell Biology. Mar;17(3):196-203. Review. PMID: 25720959
  7. Niederriter AR, Varshney A, Parker SCJ, and Martin DM. Super Enhancers in cancers, complex disease, and developmental disorders. Genes. 2015 Nov 9;6(4):1183-200. Review. PMID: 26569311
  8. Peti W & Page R. (2015) Perspective: Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: Achieving specificity by targeting substrate and regulatory protein interaction sites. Bioorganic & Medicinal Chemistry, 23 (12), 2781-2785. PMID: 25771485
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